Missionbio

See how **single-cell DNA + DNA methylation + surface protein** profiling with **scTAM-seq (on Tapestri)** dissects treatment response in **MDS/AML** using **sequential patient bone-marrow samples** collected during targeted therapy.

*   **Multi-omic resolution, one assay:** scTAM-seq simultaneously profiles **somatic mutations, methylation, and protein** at single-cell resolution.
*   **Sharper cell typing:** Integrating **scTAM-seq + ADT-seq** improves **cell-type identification**, resolving subtle hematopoietic populations.
*   **Track clonal evolution:** Combining **scTAM-seq with single-cell genotyping** maps **clonal architecture** and **evolution under therapy** across **sequential samples**.

**Rethinking response metrics:** Understand **clinical response** that can occur **independent of changes in mutant allelic burden**, and implications for disease monitoring.
