Deconvolution of clonal dynamics with scTAM-seq

See how single-cell DNA + DNA methylation + surface protein profiling with scTAM-seq (on Tapestri) dissects treatment response in MDS/AML using sequential patient bone-marrow samples collected during targeted therapy.

• Multi-omic resolution, one assay: scTAM-seq simultaneously profiles somatic mutations, methylation, and protein at single-cell resolution.
• Sharper cell typing: Integrating scTAM-seq + ADT-seq improves cell-type identification, resolving subtle hematopoietic populations.
• Track clonal evolution: Combining scTAM-seq with single-cell genotyping maps clonal architecture and evolution under therapy across sequential samples.

Rethinking response metrics: Understand clinical response that can occur independent of changes in mutant allelic burden, and implications for disease monitoring.