Single-cell profiling of genome-editing alterations and functional outcomes in CRISPR-engineered cells
Mission Bio & Integrated DNA Technologies
44:10
To overcome the limitations of bulk analysis in genome editing in applications like therapeutics, which can mask critical off-target events that compromise safety, a workflow that utilizes single-cell insights is required. Here, you will learn how Integrated DNA Technologies' rhAmpSeq™ and UNCOVERseq technology with Mission Bio’s Tapestri® single-cell DNA sequencing platform create a comprehensive, high-sensitivity workflow for the detection of on- and off-target editing.
Join Nechama Kalter from Bar-Ilan University as she walks through her latest work that utilizes this workflow to assess the fidelity, safety, and functional consequences of CRISPR-based genome editing.
Speakers
Nechama Kalter, Ph.D. student, Ayal Hendel Lab, Bar-Ilan University
Adam Chernick, Sr. Commercial Product Manager, Integrated DNA Technologies
Michael Molnar, Sr. Marketing manager, Mission Bio
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Speaker
Nechama Kalter
PhD Student
Nechama Kalter is a Ph.D. student in the Department of Life Sciences at Bar-Ilan University, conducting research in Prof. Ayal Hendel’s lab. Her work focuses on developing computational tools for CRISPR-Cas9 off-target analysis. She holds an M.Sc. (cum laude) in Molecular Biology and a B.Sc. (magna cum laude) in Neuroscience, both from Bar-Ilan University.
Single-cell profiling of genome-editing alterations and functional outcomes in CRISPR-engineered cells
44:10